2 edition of The Xanthone effect found in the catalog.
The Xanthone effect
Morton, David A.
Includes bibliographical references (p. 37-43).
|Statement||David A. Morton.|
|LC Classifications||QK899 .M67 2005|
|The Physical Object|
|Pagination||43 p. ;|
|Number of Pages||43|
|LC Control Number||2007281410|
Wayl ( or [micro]g) completely reversed the effects of (+) 8-OHDPAT ( [micro]g), and potentiated the anti-immobility effect of the ineffective dose of xanthone ( ng) in the FST. The association of effective doses of (+) 8-OH-DPAT ( fig) and xanthone ( ng) annulled the effect of each compound on immobility time. Bioavailability and antioxidant effects of a xanthone-rich Mangosteen product in humans. J Agric Food Chem. Brunswick Laboratories, Norton, Massachusetts, USA. This study investigated the absorption and antioxidant effects of a xanthone-rich mangosteen liquid in healthy human volunteers after the acute consumption of 59 mL of the supplement.
Gentiana kokiana is a xanthone-containing herb commonly used for the treatment of hypertension in Italy (Uncini-Manganelli et al., ). The vasodilator effect of crude extract and xanthones from G. kokiana was described as the mechanism of its antihypertensive activity (Baragatti et al., ; Chericoni et al., ). Title: Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement VOLUME: 5 ISSUE: 4 Author(s):Young-Won Chin and A. Douglas Kinghorn Affiliation:Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH , USA.
Xanthones have been reported to induce QR and inhibit P activity [46, 47], suggesting that these substances may have potential uses for preventing cancer initiation. Currently, however, there has been limited study regarding the inhibitive effects of xanthones on phase I and II enzymes, and warrant further investigation. Xanthones are a class of chemical compounds, similar to vitamins, in that xanthones help the body’s cells to function correctly and optimally. A xanthone is composed of 3 diamond shaped rings resembling a part of a honey comb. Carbon and oxygen atoms make of the atomic backbone.
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Scientists have now isolated mangosteen’s active ingredients, called xanthones, which have been attributed to the fruit’s healing properties. In this phenomenal book Dr.
David Morton gives an in-depth look at how xanthones are linked to the Author: David Morton. Xanthone (Xa) and 1-OH Xanthone (1-OHXa) in 1,2-dipalmitoyl-sn-glycerophosphocholine (DPPC) membranes increase the dipole s with 1,2-di-O-tetradecyl-sn-glycerophosphocholine (Ether PC), lacking carbonyl groups, indicate that the CO dipole of Xa molecule does not contribute to the increase of dipole lar Dynamics calculations confirm that Cited by: 2.
Results: The oral acute toxicity studies of 2 xanthone derivatives ( and ) did not show any toxic effect until the dose at mg/kg body weight, and xanthone derivatives and resulted in a significant decrease of the immobility period (in seconds) compared with the untreated control group during the forced swim test with rats.
A remarkable improvement of this effect promoted by encapsulation of these compounds in nanocapsules of poly (dl-lactide-co-glycolide) (PLGA) is also demonstrated. A weak inhibitory effect of % on NO production by activated macrophages was observed for xanthone at the highest studied concentration ( μM).Cited by: 4.
Growth Inhibitory Effect of Prenylated Xanthones. The major 4 structurally similar prenylated xanthones [α-mangostin (αM), β-mangostin (βM), γ-mangostin (γM), and methoxy-β-mangostin (βM–ME)] from the pericarps of mangosteen wereexamined for the effect on the growth of human colon cancer DLD-1 cells (Figure 2).Except formethoxy-β-mangostin, other xanthones Cited by: Results.
The oral acute toxicity studies of 2 xanthone derivatives ( and ) did not show any toxic effect until the dose at mg/kg body weight, and xanthone derivatives and resulted in a significant decrease of the immobility period (in seconds) compared with the untreated control group during the forced swim test with rats (dose = 12 mg/kg; P.
Consuming Xanthone Plus two to three times a day will help to relieve pain through its anti-inflammatory and cox-2 inhibitor effects. Alzheimer’s One of the major health benefits of Xanthone Plus is its effectiveness in treating Alzheimer’s disease.
Xanthone is an organic compound with the molecular formula C 13 H 8 Oxanthone was introduced as an insecticide and it currently finds uses as ovicide for codling moth eggs and as a larvicide.
Xanthone is also used in the preparation of xanthydrol, which is used in the determination of urea levels in the blood. It can also be used as a photocatalyst. Matsumoto K, Akao Y, Kobayashi E, et al. Induction of aptosis by xanthones from mangosteen in human leukemia cell lines.
J Nat Prod ; View abstract. It showed cytotoxic effects to leukemia, breast, gastric, lung, and liver cancer cell lines. However, xanthones mediate anticancer effects through downregulation of c-MYC mRNA expression/telomerase reverse transcriptase gene and initiate apoptosis, arresting immortalization, and proliferation of human cancer cells (Zhang et al., ).
Most likely, the biosynthetic pathway of the majority of xanthones present in Centaurium species goes via 1,3,5-trihydroxyxanthone (Fig. ), a tri-substituted xanthone, which arises from 2,3′,4,6-tetrahydroxybenzophenone in a reaction catalyzed by xanthone synthase .
1,3,5-Trihydroxyxanthone (Fig. ) could putatively be the precursor of other tri- tetra- penta- and. Mangosteen (Garcinia mangostana L.; Clusiaceae) is a popular botanical dietary supplement in the United States, where it is used principally as an antioxid. The Xanthone Effect – Centuries of Science Simplified For centuries people in Southeast Asia used the mangosteen fruit for traditional healing applications such as diarrhea, dysentery, pain, ulcers, and infections.
Emerging research, coupled with its use in traditional medicine, is propelling mangosteen into the spotlight. reported the anti-proliferation ac tivities of all the 26 xanthones including 20 xanthones from this plant in our previous report . That work used HepG2, A, SGC, and MCF-7 cells.
absorption and antioxidant effects of a xanthone-rich mangosteen liquid in healthy human volunteers after the acute consumption of 59 mL of the suppleme nt. The liquid contained mangosteen, aloe vera, green tea, and multivitamins. Results indicated that R-mangostin and vitamins B 2 and B 5 were bioavailable, with observed C max at t max of.
this book emphasize key studies about xanthones that have had a significant impact on the interpretation of the health and the effects of xanthones on the body. Please use the information contained in this book to learn more regarding xanthones from the mangosteen fruit, and their effects on the human body and on various conditions of health.
Mangosteen, Garcinia mangostana Linn, is a tree found in South East Asia, and its pericarps have been used as traditional medicine. Phytochemical studies have shown that they contain a variety of secondary metabolites, such as oxygenated and prenylated xanthones.
Recent studies revealed that these xanthones exhibited a variety of biological activities containing anti-inflammatory, anti. Xanthones of Mammea americana exhibited inhibitory activity against sarcoma tumor cell. 1,8-Dihydroxy-3,5-dimethoxyxanthone (swerchirin), isolated from the hexane fraction from Swertia chirayita, has a very significant blood sugar lowering effect in fasted, fed, glucose loaded, and tolbutamide pretreated albino rats.
Direct cytotoxic effects of the xanthones were established by IC50 estimation based on XTT assay. Results: 5 compounds of the total 17 showed significant cytotoxicity toward the studied cancer cultures and were submitted to further detailed analysis, including studies examining their influence on gelatinase A and B expression, as well as on the.
Xanthones are close cousins to the polyphenols family and have strong antioxidant effects on the nervous system. They are found in several botanical tonics, including St. John’s wort, gentian root nectar, and mangosteen.
Current research on Xanthones suggests that they are beneficial in helping with many conditions, including allergies, infections (microbial, fungus, viral), cholesterol. Xanthone Plus Herbal Capsule is made of Malunggay and Mangosteen.
Let's fight Cancer together! Take 2 to 3 capsules daily - 30 minutes before or after meal a. The effects of mangosteen xanthones on mammary cancer have been examined in two studies using mammary BJMC cancer cells xenografted into Balb/c mice. Subcutaneous α-MG [ 17 ] and dietary Panaxanthone (75%–85% α-MG and 5%–15% γ-MG) [ 18 ] significantly suppressed tumor volumes and metastastic expansion in this cancer model.Alcohol Effect on Equilibrium Constants and Dissociation Dynamics of Xanthone−Cyclodextrin Complexes Yuan Liao and Cornelia Bohne The Journal of Physical Chemistry (2),